2-Bromo-para-methylpropiophenone (2 Bromo 4 methylpropiophenone)
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Examination of its use cases from laboratory lacrimator to a pillar of leukemia therapy.
2 Bromo 4 methylpropiophenone: General data
| Molecular formula: | C10H10BrO |
| Molecular weight: | 227.10 g/mol |
| Purity: | 98.0% |
| Density: | 1.357 g/cm3 |
| Appearance: | White to off-white crystalline powder |
This multi-purpose electrophilic aromatic ketone is used as a building block in the medicinal chemistry and advanced organic synthesis. Its molecular structure allows efficient participation in nucleophilic substitution and carbon-carbon bond-forming reactions.
These properties are valuable for the rapid scaffold construction and fragment assembly during early-stage drug discovery.
2 Bromo 4 methylpropiophenone: Drug discovery advantage
2-bromo-1-(4-methylphenyl)propan-1-one (the synonym IUPAC name) is a practical building block for medicinal chemistry teams. During the lead generation process, the alpha-bromo ketone functionally provides a reactive “handle” for nucleophilic substitution. That enables Here’s how it helps drug discovery.
The role of 2 Bromo 4 methylpropiophenone in fragment assembly
As an electrophilic ketone, it lets chemists attach diverse fragments with predictable reactivity. It facilitates the synthesis of molecular scaffolds.
2 Bromo 4 methylpropiophenone: benefits for SAR work
Its predictable reactivity and ease of purification speed up the preparation of analog series for structure–activity relationship studies.
From bench to preclinical scale
When moving from milligram to kilogram scale, choose suppliers who provide batch CoA, stability data and reliable logistics to avoid delays.
Regulatory record-keeping
Document material provenance and analytical results to support regulatory filings and protect IP during development.
Breakthrough in Oncology
The most compelling use case of 2-bromo-1-(4-methylphenyl)propan-1-one is oncology. This intermediate was used used during recent studies to synthesize inhibitors, targeting the specific signaling pathways in leukemia cells.
Conclusion
2-Bromo-para-methylpropiophenone is a practical, dependable intermediate that accelerates medicinal chemistry workflows.
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